ine, LSD6, bufotenine, muscarine successful in many cases. Bulbocapnine induces a state approximating schizophrenic catatonia . . . instances of automatic obe­dience have been observed. Bulbocapnine is a back- brain depressant probably putting out of action the centers of motion in the hypothalamus. Other drugs that have produced experimental schizophrenia—mescaline, harmaline, LSD6—are backbrain stimulants. In schizo­phrenia the backbrain is alternately stimulated and depressed. Catatonia is often followed by a period of excitement and motor activity during which the nut rushes through the wards giving everyone a bad time. Deteriorated schizos sometimes refuse to move at all and spend their lives in bed. A disturbance of the regu­latory function of the hypothalamus is indicated as the ‘cause’ (causal thinking never yields accurate description of metabolic process—limitations of existing language) of schizophrenia. Alternate doses of LSD6 and bulbo­capnine—the bulbocapnine potientiated with curare- give the highest yield of automatic obedience.“There are other procedures. The subject can be re­duced to deep depression by administering large doses of benzedrine for several days. Psychosis can be induced by continual large doses of cocaine or demerol or by the abrupt withdrawal of barbiturates after prolonged ad­ministration. He can be addicted by dihydro-oxy-heroin and subjected to withdrawal (this compound should be five times as addicting as heroin, and the withdrawal proportionately severe).“There are various ‘psychological methods/ compul­sory psychoanalysis, for example. The subject is re­quested to free-associate for one hour every day (in